姓名：張亞卓 性別：男 職稱：教授
招生類型：科學(xué)與專業(yè)學(xué)位(碩) 科學(xué)與專業(yè)學(xué)位(博)
招生專業(yè)：外科學(xué)（神外）(碩) 外科學(xué)（神外）(博)
研究方向：垂體瘤與顱底脊索瘤的基礎(chǔ)與臨床研究
電子信箱：zyzxizxg@public.bta.net.cn
社會(huì)任職
1. 中國(guó)醫(yī)師協(xié)會(huì)神經(jīng)內(nèi)鏡醫(yī)師培訓(xùn)學(xué)院院長(zhǎng)
2. 中國(guó)醫(yī)師協(xié)會(huì)內(nèi)鏡醫(yī)師分會(huì)神經(jīng)內(nèi)鏡專家委員會(huì)主任委員
3. 北京醫(yī)學(xué)會(huì)神經(jīng)外科分會(huì)主任委員
4. 中國(guó)醫(yī)師協(xié)會(huì)神經(jīng)修復(fù)學(xué)專業(yè)委員會(huì)主任委員
5. 首都醫(yī)科大學(xué)垂體腺瘤臨床診療與研究中心主任
6. 中國(guó)醫(yī)師協(xié)會(huì)內(nèi)鏡醫(yī)師分會(huì)副會(huì)長(zhǎng)
7. 《中華神經(jīng)外科雜志》總編輯
8. 世界華人神經(jīng)外科協(xié)會(huì)第三屆委員會(huì)主席
9. 北京市腦重大疾病研究院腦腫瘤研究所所長(zhǎng)
個(gè)人簡(jiǎn)歷
1. 199704- :北京市神經(jīng)外科研究所 北京天壇醫(yī)院神經(jīng)外科 主任醫(yī)師
2. 199507-199704:北京市神經(jīng)外科研究所 博士后 副主任醫(yī)師
3. 199208-199507:天津醫(yī)科大學(xué)總醫(yī)院神經(jīng)外科 攻讀博士學(xué)位
4. 198908-199208:佳木斯醫(yī)學(xué)院附屬醫(yī)院神經(jīng)外科 主治醫(yī)師
5. 198608-198908:天津醫(yī)科大學(xué)總醫(yī)院 攻讀碩士學(xué)位 主治醫(yī)師
6. 198208-198608:佳木斯醫(yī)學(xué)院附屬醫(yī)院神經(jīng)外科 住院醫(yī)師
7. 197803-198208:佳木斯醫(yī)學(xué)院醫(yī)療系 大學(xué)本科
重要學(xué)術(shù)論文
1. Jing Guo#,Chuzhong Li#,Qiuyue Fang,Yulou Liu,Dawei Wang,Yiyuan Chen,Weiyan Xie*，Yazhuo Zhang*.The SF3B1 R625H mutation promotes prolactinoma tumor progression through aberrant splicing of DLG1.Journal Of Experimental & Clinical Cancer Research.2022.41（1）.26.SCI
2. Jiwei Bai#, Jianxin Shi#, Chuzhong Li #, Shuai Wang#, Tongwu Zhang , Xing Hua, Bin Zhu , Hela Koka, Ho-Hsiang Wu , Lei Song, Difei Wang, Mingyi Wang , Weiyin Zhou,Bari J. Ballew, Bin Zhu, Belynda Hicks , Lisa Mirabello, Dilys M. Parry, Yixuan Zhai, Mingxuan Li, Jiang Du, Junmei Wang, Shuheng Zhang, .Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival.nature communications.2021.12（1）.757.SCI
3. Chuzhong Li#,Weiyan Xie#, Jared S. Rosenblum,Jianyu Zhou, Jing Guo, Yazhou Miao, Yutao Shen, Hongyun Wang, Lei Gong, Mingxuan Li,Sida Zhao, Sen Cheng, Haibo Zhu,Tao Jiang, Shiying Ling, Fei Wang, Hongwei Zhang,Zhengping Zhuang*, Yazhuo Zhang*.Somatic SF3B1 hotspot mutation in prolactinomas .Nature Communications.2021.11(1).2506.SCI
4. Mingxuan Li,Yutao Shen,Yujia Xiong ,Shuai Wang,Chuzhong Li ,Jiwei Bai *,Yazhuo Zhang *.Loss of SMARCB1 promotes autophagy and facilitates tumour progression in chordoma by transcriptionally activating ATG5.Cell Proliferation.2021.54(12).13136.SCI
5. Jiwei Bai,Mingxuan Li,Yujia Xiong,Yutao Shen,Chunhui Liu, Peng Zhao, Lei Cao,Songbai Gui,Chuzhong Li*, Yazhuo Zhang*.Proteomics Analysis Identified ASNS as a Novel Biomarker for Predicting Recurrence of Skull Base Chordoma.frontiers in oncology.2021.11.698497.SCI
6. Song G, Qiu J, Li C, Li J, Gui S, Zhu H, Zhang Y*.Alterations of regional homogeneity and functional connectivity in pituitary adenoma patients with visual impairment.Scientific Reports.2017.7(1).-.SCI
7. Wang J, Liu Q, Gao H, Wan D, Li C, Li Z, Zhang Y*.EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.Tumour Biol.2017.39 (7).-.SCI
8. Wang J, Liu Q, Gao H, Wan D, Li C, Li Z, Zhang Y*.EGFL7 participates in regulating biological behavior of growth hormone-secreting pituitary adenomas via Notch2/DLL3 signaling pathway.Tumour Biol.2017.39 (7).-.SCI
9. Weiyan Xie#，Chunhui Liu，Dan Wu, Zhenye Li, Chuzhong Li， and Yazhuo Zhang*.Phosphorylation of kinase insert domain receptor by cyclindependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas.Oncotarget.2016.7.50883-50894.SCI
10. YOUTU WU#, JIWEI BAI, LINCHUAN HONG, CHUNHUI LIU, SHENGYUAN YU, GUOQIANG YU and YAZHUO ZHANG*.Low expression of secreted frizzled.related protein 2 and nuclear accumulation of β.catenin in aggressive nonfunctioning pituitary adenoma.ONCOLOGY REPORTS.2016.12.199-206.SCI
11. Youtu Wu#, Chunhui Liu, Shengyuan Yu, Hua Gao, Zhenye Li, Chuzhong Li and Yazhuo Zhang*.Assessment of sFRP4 as a bio-marker for predicting aggressiveness and recurrence of growth hormone-secreting pituitary adenomas.ONCOLOGY REPORTS.2016.35.2991-2999.SCI
12. Chunhui Liu＃, Hua Gao＃, Lei Cao, Songbai Gui, Qian Liu, Chuzhong Li, Dan Li, Lei Gong, and Yazhuo Zhang＊.The Role of FSCN1 in Migration and Invasion of Pituitary Adenomas.Mol Cell Endocrinol..2016.419.217-24.SCI
13. Hua Gao, Fei Wang, Xiaolei Lan, Chuzhong Li, Jie Feng, Jiwei Bai, Lei Cao, Songbai Gui,Lichuan Hong and Yazhuo Zhang＊.Lower PRDM2 expression is associated with dopamine-agonist resistance and tumor recurrence in prolactinomas. .BMC TUMOR.2015.15(1).272.SCI
14. Wu Y, Bai J, Li Z, Wang F, Cao L, Liu C, Yu S, Yu G, Zhang Y*.Low expression of secreted frizzled-related protein 4 in aggressive pituitary adenoma.Pituitary.2015.18(3).335-42.SCI
15. Li Z, Liu Q, Li C, Zong X, Bai J, Wu Y, Lan X, Yu G, Zhang Y*.The role of TGF-β/Smad signaling in dopamine agonist-resistant prolactinomas.molecular and cellular endocrinology.2015.402.64-71.SCI
16. Xie W, Wang H, He Y, Li D, Gong L, Zhang Y*.CDK5 and its activator P35 in normal pituitary and in pituitary adenomas: relationship to VEGF expression.Int J Biol Sci.2014.10(2).192-199. .SCI
17. Cao L, Gao H, Gui S, Bai G, Lu R, Wang F, Zhang Y*.Effects of the estrogen receptor antagonist fulvestrant on F344 rat prolactinoma models.J Neurooncol.2014.116(3).523-531.SCI
18. Hong L, Wu Y, Feng J, Yu S, Li C, Wu Y, Li Z, Cao L, Wang F, Zhang Y*.Overexpression of the cell adhesion molecule claudin-9 is associated with invasion in pituitary oncocytomas.human pathology.2014.45（12）.2423-2429.SCI
19. Zhenye L, Chuzhong L, Youtu W, Xiaolei L, Lei C, Lichuan H, Hongyun W, Yonggang W, Fei W, Yazhuo Z*.The expression of TGF-β1, Smad3, phospho-Smad3 and Smad7 is correlated with the development and invasion of nonfunctioning pituitary adenomas.journal of translational medicine.2014.12.71.SCI
20. 姜之全，桂松柏，張亞卓*.Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays.J Neurooncol.2012.108（3）.341-348.SCI
21. 張亞卓 .建立轉(zhuǎn)化醫(yī)學(xué)平臺(tái)、促進(jìn)神經(jīng)外科人才培養(yǎng) .中華神經(jīng)外科雜志.2010.26（11）.961-962.核心期刊
22. 裴傲; 張亞卓*; 宗緒毅; 王新生; 趙澎; 宋明;.內(nèi)鏡經(jīng)鼻蝶入路手術(shù)治療大型垂體腺瘤. 中國(guó)神經(jīng)腫瘤雜志.2009.7(1).22-24.
23. 劉方軍; 張亞卓; 趙澎; 張永力; 孫玉明; 周忠清; 王計(jì)強(qiáng); 石祥恩;.顱內(nèi)血管外膜細(xì)胞瘤的臨床診治6例分析及文獻(xiàn)復(fù)習(xí) . 中國(guó)神經(jīng)腫瘤雜志.2009.7（2).118-121.
24. 李儲(chǔ)忠; 趙澎; 宗緒毅; 桂松柏; 劉方軍; 張亞卓*.單鼻孔內(nèi)鏡下經(jīng)蝶、擴(kuò)大經(jīng)蝶入路腫瘤切除術(shù)術(shù)中、術(shù)后出血原因分析及對(duì)策 .中國(guó)神經(jīng)腫瘤雜志 .2009.7（1).33-36.
25. 李儲(chǔ)忠; 張亞卓*.神經(jīng)內(nèi)鏡應(yīng)用進(jìn)展 .中國(guó)神經(jīng)精神疾病雜志.2009.35（2）.67—68.
26. 桂松柏; 張亞卓*; 王新生; 宗緒毅; 趙澎;.內(nèi)鏡顱底手術(shù)后顱內(nèi)感染的綜合治療1例報(bào)告 .中國(guó)神經(jīng)腫瘤雜志 .2009.7（1).37-38.
27. 宋明1， 張亞卓2*.內(nèi)鏡技術(shù)在中樞神經(jīng)系統(tǒng)腫瘤治療中的應(yīng)用.中國(guó)神經(jīng)腫瘤雜志.2009.7(1).1-5.
28. 趙澎1， 桂松柏1， 李儲(chǔ)忠1， 宋明2， 裴傲3， 王新生1， 宗緒毅1， 張亞卓*.神經(jīng)內(nèi)鏡治療腦室內(nèi)腫瘤20 例臨床經(jīng)驗(yàn).中國(guó)神經(jīng)腫瘤雜志.2009.7(1).7-13.
29. 桂松柏，張亞卓*孫梅珍.氧化損傷星形膠質(zhì)細(xì)胞與骨髓基質(zhì)細(xì)胞共培養(yǎng)的實(shí)驗(yàn)研究 .中華神經(jīng)醫(yī)學(xué)雜志 .2008.7（3）.267-272.
30. 趙澎，張亞卓*.Reversion of nultidrug resistance in human glioma by RNA interference .Neurological Research.2008.30.562~566.
31. 嚴(yán)耀華，張亞卓*.三腦室底造瘺中的心率變化.中華神經(jīng)外科雜志.2008.24(3).193-195.
32. 宋明，張亞卓*，王新生，宗緒毅.內(nèi)鏡下經(jīng)鼻入路顯露視神經(jīng)和眼眶的解剖研究.中國(guó)內(nèi)鏡雜志.2008.14(4).357-360.
33. 劉方軍，張亞卓*，桂松柏，孫澤林.F90對(duì)膠質(zhì)母細(xì)胞瘤的作用及機(jī)制研究.中國(guó)微侵襲神經(jīng)外科雜志.2008.13(5).220-222.
主編或副主編的著作/譯著
1. 《內(nèi)鏡神經(jīng)外科學(xué)（第3版）》,主編,人民衛(wèi)生出版社,202211
2. 《神經(jīng)內(nèi)鏡手術(shù)規(guī)范化培訓(xùn)教程》,主編,人民衛(wèi)生出版社,201804
3. 《內(nèi)鏡神經(jīng)外科學(xué)（第2版）》,主編,人民衛(wèi)生出版社,201705
4. 《內(nèi)鏡神經(jīng)外科學(xué)》,主編,人民衛(wèi)生出版社,201207
5. 《《腦室外科學(xué)》》,主編,人民衛(wèi)生出版社,201101
6. 《內(nèi)鏡顱底外科(翻譯版)》,主譯,科學(xué)出版社,201003
7. 《神經(jīng)內(nèi)鏡手術(shù)技術(shù)》,主編,北京大學(xué)醫(yī)學(xué)出版社,200403
8. 《腦室外科手術(shù)學(xué)》,主編,中國(guó)協(xié)和醫(yī)科大學(xué)出版社,200110
重要獎(jiǎng)項(xiàng)
1. 顱底內(nèi)鏡技術(shù)研發(fā)轉(zhuǎn)化與應(yīng)用 北京市科技進(jìn)步二等獎(jiǎng) 2012
2. 微侵襲神經(jīng)內(nèi)鏡應(yīng)用技術(shù)的研究 市三等（1） 2003
3. 微侵襲內(nèi)鏡神經(jīng)外科應(yīng)用技術(shù)研究 中華醫(yī)學(xué)獎(jiǎng)三等 2003
4. 微侵襲內(nèi)鏡神經(jīng)外科應(yīng)用技術(shù)研究 北京市科技技術(shù)獎(jiǎng)三等獎(jiǎng) 2003
5. 腦干腫瘤的基礎(chǔ)與臨床研究 市二等 2000
